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Dr. Maha Othman, MD, MSc, PhD
Professor: Laurentian University/St. Lawrence College Collaborative BScN Program Kingston, Ontario, Canada http://www.stlawrencecollege.ca/index.aspx?iPageID=56&iMenuID=6&iCurrID=12.
Assistant Professor: Queens University, Biomedical and Molecular Sciences, Kingston, Ontario, Canada http://meds.queensu.ca/departments/biomedical_molecular_sciences
Email: othman@queensu.ca
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Previous Training/Positions:
Postdoctoral training at Dr. David Lillicrap’s research Lab, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Oct 2003-Feb 2005.Senior Research Associate, Dr. David Lillicrap ‘s group, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario. Mar 2005-Aug 2009 Clinical training in Haematology/ Haemostasis (3 years residency), Mansoura University, Egypt
Research Interests:
Hemostasis has always been the most attractive area of research to me. Three major areas are the focus of my interests: Molecular genetics and diagnosis of Platelet type and type 2B Von Willebrand disease, Thromboelastography as a global haemostatic test in haematological and non haematological diseases and Platelet- adenovirus interactions. Specific research interests/ projects include:
Platelet type- von Willebrand disease (PT-VWD):
Mutations in the platelet GPIBA gene causing this rare autosomal dominant bleeding disorder. I have identified and characterized a novel mutation in the macroglycopeptide region of the GPIBA gene in three members of a British family with PT-VWD phenotype and has coordinatd an international project for the differential identification between the two closely similar disorders type 2B and PT-VWD based on genetic analysis . The results of this project is now published. For more info refer to http://www.pt-vwd.org/
Thromobelastography (TEG) studies:
We have demonstrated a wide inter and intra individual variations in the TEG pattern in hemophilia A dogs. We have also shown that acute exercise improves the global hemostatic efficacy in those hemophilic animals as shown by the changes in their TEG patterns. We evaluated the role of thromboelastography as a sensitive hemostatic tool to monitor the rFVII treatment in hemophilia A dogs.We are also investigating the role of TEG in determining haemostatic abnormalities in two medical conditions: Obstructive sleep apnea (OSA) and pre eclampsia. We are studying the TEG changes following inspiratory occlusion in anaesthetized rats to model OSA and also in LPS- treated pregnant rats to model pregnancy complication.
Platelet- adenovirus interactions
We investigated the mechanism of acute thrombocytopenia that follows adenovirus administration and approaches to prevent this adverse effect. We have demonstrated a novel expression of CAR on human platelets and a critical role for the platelet P-selectin and the VWF protein in mediating adenovirus induced platelet clearance and currently studying the detailed adenovirus/ platelet interactions (binding/ internalization) both in vitro using human platelets and in vivo using mice platelets.
Recent Publications:
2011
Hamilton A, Ozelo M, Leggo J, Notley C, Brown H, Frontroth JP, Angelillo-Scherrer A, Baghaei F, Enayat SM, Favaloro E J, Lillicrap D, Othman M . Frequency of Platelet type versus Type 2B von Willebrand Disease: results of an International registry based study. Thromb Haemost. 2011 Mar 1;105(3):501-8.
Chegeni R, Vickars L, Favaloro EJ, Lillicrap D, Othman M. Functional analysis of three recombinant A1-VWF domain mutants in comparison to wild type and plasma -derived VWF facilitates subtyping in type 2 von Willebrand disease. Thromb Res. 2011 Feb;127(2):161-6
Renaud SJ, Cotechini T, Quirt JS, macdonald-Goodfellow SK, Othman M, Graham CH. Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. J Immunol. 2011 Feb 1;186(3):1799-808.
Chitlur M, Sorensen B, Rivard GE, Young G, Ingerslev J, Othman M, Nugent D, Kenet G, Escobar M, Lusher J. Standardization of Thromboelastography: A Report from the TEG-ROTEM Working Group. Haemophilia 2011 Feb 15 [Epub ahead of print]
2010
Othman M, Gordon SP, Iscoe S. Repeated inspiratory occlusions in anesthetized rats acutely increase blood coagulability as assessed by thromboelastography. Respiratory Physiology & Neurobiology, 2010, 61-66
Othman M, Powell S, Hopman WM, Lillicrap D. Variability of thromboelastographic responses following the administration of rFVIIa to haemophilia A dogs supports the individualization of therapy with a global test of haemostasis. Haemophilia, 2010 Nov;16(6):919-25
Othman M, Chirinian Y, Brown C, Notley C, Hickson N, Hampshire D, Buckley S, Waddington S, Parker AL, Baker A, James P, Lillicrap D. Functional characterization of a 13 bp deletion (c.-1522 -1510del 13 in the promoter of the von Willerbrand factor gene in type 1von Willebrand disease. Blood. 2010; 116(18): 3645-3652.
Othman M, Powell S, Hopman W, Lillicrap D.Variability of hromboelastographic Responses Following the Administration of rFVIIa to Hemophilia A dogs supports the Individualization of Therapy with a Global Test of Hemostasis. Haemophilia 2010 Nov;16(6):919-25
Othman and Hamilton. Platelet-type von Willebrand disease: results of a worldwide survey from the Canadian PT-VWD project. Acta Haematol. 2010;123(2):126-8.
2009
Othman M, Chirinian Y, Hegadorn C, Powell S, Hopman W , Lillicrap D. Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise. Hemophilia 2009 1-9. I
Qadura M, Waters B, Burnett E, Chegeni R, Bradshaw S, Hough C, Othman M, Lillicrap D. Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice. Blood. 2009
2008
Qadura M, Othman M, Waters B, Chegeni R, Walker K, Labelle A, Ozelo M, Hough C, Lillicrap D. Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemost. 2008 (12):2095-104.
Othman M. Differential identification of PT-VWD from type 2B VWD and GP1BA nomenclature issues. British Journal of Haematology, 2008; 142 (2): 312-314
Othman M. Moelcular genetic testing in hemostasis and thrombosis: the past, the present and the future. Semin Thromb Hemost. 2008 Sep;34(6):485-9.
Othman M. Differential identification of PT-VWD from type 2B VWD and GP1BA nomenclature issues. British Journal of Haematology, 2008; 142: 308–326
2007
Othman M. Platelet-Type von Willebrand Disease and Type 2B von Willebrand Disease: A Story of Nonidentical Twins when Two Different Genetic Abnormalities Evolve into Similar Phenotypes Semin Thromb Hemost 2007; 33: 780-786
Othman M, Elbatarny HS, Byrne CD, and O’Shaughnessy DF. Von Willebrand Factor Short Sequence Repeat Locus 2 (Intron 40) Consists of Three Polymorphic Subloci. Acta Hemaologica 2007,117(3):177-80.
Othman M, Labelle A, Mazzetti I,Elbatarny HS, Lillicrap D: Adenovirus induced thrombocytopenia: the role of P-selectin and von Willebrand factor in virus- mediated platelet clearance. Blood 2007, 109(7):2832-9.
Paula D. James, Colleen Notley, Carol Hegadorn, Jayne Leggo, Angie Tuttle, Shawn Tinlin, Christine Brown, Chandler Andrews, Andrea Labelle, Yvette Chirinian, Lee O’Brien, Maha Othman, Georges Rivard, Dilys Rapson, Christine Hough, David Lillicrap, for the Association of Hemophilia Clinic Directors of Canada, The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study Blood 2007;109: 145-154.